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    The Hacking of the American Mind

    Page 34
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    23.Epel ES et al., “The Reward-Based Eating Drive Scale: A Self-Report Index of Reward-Based Eating.” PLoS One 9, e101350 (2014).

      24.Mason AE et al., “Reduced Reward-Driven Eating Accounts for the Impact of a Mindfulness-Based Diet and Exercise Intervention on Weight Loss: Data from the SHINE Randomized Controlled Trial.” Appetite 100, 86–93 (2016).

      25.Wang GJ et al., “BMI Modulates Calorie-Dependent Dopamine Changes in Accumbens from Glucose Intake.” PLoS One 9, e101585 (2014).

      26.Filbey FM et al., “Reward Circuit Function in High BMI Individuals with Compulsive Overeating: Similarities with Addiction.” Neuroimage 63, 1800–6 (2012).

      27.Karlsson HK et al., “Obesity Is Associated with Decreased ß-Opioid but Unaltered Dopamine D2 Receptor Availability in the Brain.” J. Neurosci. 35, 3959–65 (2015).

      28.Tuominen L et al., “Aberrant Mesolimbic Dopamine-Opiate Interaction in Obesity.” Neuroimage 122, 80–86 (2015).

      29.Langleben DD et al., “Depot Naltrexone Decreases Rewarding Properties of Sugar in Patients with Opioid Dependence.” Psychopharmacology 220, 559–64 (2012).

      30.Mason AE et al., “Acute Responses to Opioidergic Blockade as a Biomarker of Hedonic Eating Among Obese Women Enrolled in a Mindfulness-Based Weight Loss Intervention Trial.” Appetite 91, 311–20 (2015).

      31.Mason AE et al., “Putting the Brakes on the ‘Drive to Eat’: Pilot Effects of Naltrexone and Reward-Based Eating on Food Cravings Among Obese Women.” Eat Behav. 19, 53–6 (2015).

      32.Daubenmier J et al., “Effects of a Mindfulness-Based Weight Loss Intervention in Adults with Obesity: A Randomized Clinical Trial.” Obesity 24, 794–804 (2016).

      33.Moss M, Salt, Sugar, Fat: How the Food Giants Hooked Us. Random House, New York (2013).

      34.Garber AK et al., “Is Fast Food Addictive?” Curr. Drug Abuse Rev. 4, 146–62 (2011).

      35.U.S. General Accounting Office, “Food Safety: FDA Should Strengthen Its Oversight of Food Ingredients Determined to Be Generally Recognized as Safe (GRAS).” US GAO, Washington, D.C. (2010). http://www.gao.gov/products/gao-10-246

      36.Card MM et al., “Just a Spoonful of Sugar Will Land You Six Feet Underground: Should the Food and Drug Aministration Revoke Added Sugar’s GRAS Status?” Food and Drug Law Journal 70, 395 (2015).

      37.Lustig RH, “GRAS: Smoke It, Don’t Eat It,” Huffington Post, June 7, 2013. http://www.huffingtonpost.com/robert-lustig-md/fda-food-additives_b_3384629.html

      38.Michail N, “Major Dutch Retailer to Cut Sugar Across Its Private Label Range.” http://www.foodnavigator.com/market-trends/major-dutch-retailer-to-cut-sugar-across-its-private-label-range

      39.Kaminska I, “Robert Lustig: Godfather of the Sugar Tax” Financial Times, London (2016). http://www.ft.com/cms/s/0/311a74ec-ed24-11e5-888e-2eadd5fbc4a4.html?siteedition=intl—axzz4hkmj2rq0

      40.Popkin BM et al., “Sweetening of the Global Diet, Particularly Beverages: Patterns, Trends, and Policy Responses.” Lancet Diab. Endocrinol. 4, 174–86 (2016).

      41.Interview with Ted Miguel, economist at University of California, Berkeley. http://www.gatesfoundation.org/global-development/pages/ted-miguel-interview-water-sanitation-hygiene.aspx

      42.Kearns CE et al., “Sugar Industry and Coronary Heart Disease Research: a Historical Analysis of Internal Industry Documents.” JAMA Intern. Med. 176, 1680–5 (2016).

      43.Kearns CE et al., “Sugar Industry Influence on the Scientific Agenda of the National Institute of Dental Research’s 1971 National Caries Program: A Historical Analysis of Internal Documents.” PLoS Med. 12, e1001798 (2015).

      44.Bes-Rastrollo M et al., “Financial Conflicts of Interest and Reporting Bias Regarding the Association Between Sugar-Sweetened Beverages and Weight Gain: A Systematic Review of Systematic Reviews.” PLoS Med. 10, e1001578 (2013).

      45.O’Connor A, “Coca-Cola Funds Scientists Who Shift Blame for Obesity Away from Bad Diets,” New York Times, Aug. 9, 2015. http://well.blogs.nytimes.com/2015/12/01/research-group-funded-by-coca-cola-to-disband/?_r=0

      46.Aaron DG et al., “Supporting Public Health to Deflect Coke and Pepsi Sponsorship of National Health Organizations by Two Major Soda Companies.” Am. J. Prev. Med. 52, 20–30 (2017).

      47.Dewey C, “How Nutella Plans to ‘Trick’ You into Thinking It’s Healthier Than It Is.” Washington Post Wonkblog, Jan. 9, 2017. http://www.standard.net/National/2017/01/09/How-Nutella-plans-to-trick-you-into-thinking-its-healthier-than-it-is

      48.Mandrioli D et al., “Relationship Between Research Outcomes and Risk of Bias, Study Sponsorship, and Author Financial Conflicts of Interest in Reviews of the Effects of Artificially Sweetened Beverages on Weight Outcomes: A Systematic Review of Reviews.” PLoS One 11, e0162198 (2016).

      49.Lustig RH, “Processed Food: An Experiment That Failed.” JAMA Pediatr. 171, 212-4 (2017).

      INDEX

      The page numbers in this index refer to the printed version of this book. The link provided will take you to the beginning of that print page. You may need to scroll forward from that location to find the corresponding reference on your e-reader.

      Page numbers in italics indicate figures.

      ackee fruit, 87–88

      action (regulation mode, dopamine and serotonin), 52–53, 105

      action, marketing. See hedonic marketing platform (Eyal)

      “acute” love (Earp), 39–40

      addiction, 2, 69–93

      alcohol, 47, 72, 73, 74–75, 78, 80, 81, 82, 83, 84, 85–86, 86–87, 90, 91, 92

      anxiety and, 62, 75

      cortisol and, 70

      dopamine and, 40, 47, 55–57, 69, 70, 72, 73–74, 75, 76, 79, 80, 81, 82, 83, 86, 87, 130

      dopamine-cortisol-serotonin connection, 140, 142, 144, 146, 147, 147

      Four Cs of Contentment, 225, 232, 251, 256, 264, 266, 267, 273, 274, 275, 281, 282

      hacking of the American mind, 2, 7, 9, 10, 13, 159, 162–63, 183, 184, 187, 188, 196, 206, 210

      love, 39–41

      neuroscience, 32, 34

      obesity and, 80

      processed food, 87–89

      reward and, 25, 46

      serotonin and, 97, 112–13, 115, 117, 119, 120, 129–30, 131

      sleep and, 72

      stress and, 65

      sugar, 72, 80, 82, 83, 84, 87–89, 89–92, 202, 282

      See also alcohol; dependence; dopamine; neuroscience; pleasure; sugar; tolerance; withdrawal

      addiction transfer, 80–83, 232

      adrenal glands, 60, 63

      adverse childhood experiences (ACEs), 144

      Affair to Remember, An (movie), 39

      African-Americans, 61, 107, 153, 268, 271

      agape, 37

      agitated depression, 99, 99

      agony of ecstasy. See reward

      Agricultural Adjustment Act, 183

      Albert Heijn grocery chain (Netherlands), 276

      alcohol

      addiction, 47, 72, 73, 74–75, 78, 80, 81, 82, 83, 84, 85–86, 86–87, 90, 91, 92

      dopamine-cortisol-serotonin connection, 140, 146

      Four Cs of Contentment, 226, 232, 270

      hacking of the American mind, 9, 10, 25, 155, 159, 165, 181, 188–89, 200, 201, 202, 208, 209

      neuroscience, 29, 34

      serotonin and, 112, 117, 119

      See also addiction

      alpha male, 64–65

      altruism, 243–46, 248, 249

      altruistic punishment, 244

      Alzheimer’s disease, 128, 129, 206

      amygdala, 30, 31, 31, 62–63, 64, 65, 66, 67, 143, 145, 181, 210, 228, 251, 252, 256, 258

      See also cortisol

      anandamide, 33, 62, 134

      Anderson, Jack, 179

      anhedonia, 194

      animal studies, 11, 36, 102–3

      antidepressants,
    53, 55, 99, 99, 100, 103, 105, 106, 108, 122, 139, 140, 263

      antipsychotics, 49, 49, 53–54, 227

      anxiety

      addiction and, 62, 75

      dopamine-cortisol-serotonin connection, 137, 142, 146

      Four Cs of Contentment, 223, 225, 234, 239, 241, 247, 251, 255, 259–60, 263

      hacking of the American mind, 163–64, 179, 189, 193–94, 196, 197, 210

      neuroscience, 33, 34, 35, 37

      serotonin and, 100, 105, 107, 112, 115, 116, 117, 129, 134–35

      See also stress

      apoptosis, 71, 72, 74

      apps, 265–66

      Archer Daniels Midland, 183

      Aristotle, 8, 19, 23–24, 24, 160, 168

      artificial sweeteners, 278–79

      Aspiration Index, 239

      atheism, 226

      “Attack on the American Free Enterprise System” (Powell), 178

      Avena, Nicole, 88

      aversion to harm, 245

      Awakenings (movie), 79

      “bad trips” (hallucinogens), 111–12, 115, 117, 118, 119, 120, 223, 224

      Baha’i faith, 20, 224

      balance of power (individual vs. corporation), 175–85, 186, 239–41

      bariatric surgery, 80–81

      Beck Anxiety Inventory, 193–94

      Beck Depression Inventory (BDI), 101

      beef, 125–27

      behavioral disorders, 54, 55

      behaviors, addiction, 76, 77–79

      Bellotti, First National Bank of Boston v., 180

      bell-shaped curve, dopamine, 34, 48–51, 49, 53, 55, 59, 64, 67

      Ben-Shahar, Tal, 22

      Bentham, Jeremy, 23–24

      beta-endorphin, 56, 58, 263

      big belly (visceral) fat, 261, 262, 263, 264, 271

      big butt (subcutaneous) fat, 261, 271

      Bill of Rights, 176, 177

      bingeing, 76, 86, 88, 91, 128, 138, 141, 194, 255, 274

      biochemistry and behavior, 2, 5, 6–7, 10–11, 14, 25, 26–27, 29, 34, 36, 37, 120–21, 137, 173–74

      bipolar disorder (manic-depressive illness), 105

      “black hat” hacking, 3

      Blankfein, Lloyd, 186

      blood-brain barrier, 104, 123, 124

      Board of Education, Brown v., 178

      body mass index (BMI), 66, 247, 262

      boiling point, sugar raising, 270

      Bok, Derek, 165

      Bosch, Hieronymus, 17

      brain, 28–32, 29, 30, 31

      See also neuroscience; specific parts of the brain

      brain food (omega-3s), 132–35, 136, 137, 238, 274, 275

      Brando, Marlon, 72

      Brave New World (Huxley), 285

      Brent, Sarah, 158, 159

      Brown, Kantar Millward, 190–91

      brown, sugar turning foods, 269–70

      Brown v. Board of Education, 178

      Buckley v. Valeo, 179–80, 185

      Buddhism, 20, 171, 224, 258

      bulk, sugar adding, 269

      bullying, 195

      Bush, George H. W., 248

      Butz, Earl, 183

      Cabaret (musical), 45

      caffeine, 9, 74, 82, 83, 90, 91–92, 124, 145, 187, 200, 253, 275

      “calorie is a calorie,” 277, 278

      campaign spending, 179–80, 185

      Campbell, William, 76

      cancer, 13, 39, 71, 115, 116, 119, 126, 161, 178, 189, 202, 204, 207, 209, 210, 267, 284

      Candler, Asa, 82

      cannabis. See marijuana

      Capra, Frank, 181

      Captain Corelli’s Mandolin (Bernières), 39

      carbonation, 81, 82

      Cargill, 183

      Carhart-Harris, Robin, 118

      Carnival (musical), 45

      Carson, Rachel, 177

      Case, Anne, 155

      casino model, health insurance, 201, 214

      catechol-O-methyl transferase (COMT), 52, 52, 55, 245–46

      Caucasians, 61, 107, 154, 268

      causative studies vs. correlation, 11–12, 129, 130, 145, 193, 227, 240, 257, 268

      CBI receptor, 33, 34, 62, 133–34, 164

      cell death, 70–71, 139

      cell phones, 192–95, 197, 198, 257, 264, 266

      Central Hudson Gas & Electric Corp. v. Public Service Commission, 180–81

      cerebral cortex, 30, 30, 41

      charity, benefits of, 248–49

      Chetty, Raj, 154, 206

      children, 1–2, 67–68, 154, 187–88

      China, 85, 194, 246–47, 264, 272

      Christianity, 20, 224, 226

      Churchill, Winston, 153, 248

      CIA, 112

      cigarettes. See smoking; tobacco

      citalopram (Celexa), 100, 106, 245

      Citizens United v. Federal Election Commission, 175–76, 179, 180

      Civil War, 81, 82

      C.K., Louis, 235

      clearance (regulation mode, dopamine and serotonin), 54–55, 106

      Coates, John, 198

      Coca-Cola, 81–83, 186–87, 190, 276, 277, 278

      cocaine, 9, 49, 54, 55, 56, 57, 64, 65, 75, 82–83, 86, 90, 112–13, 141, 166, 198

      cognitive dissonance, 152, 153

      cognitive enhancement, 87

      commercial speech and governmental regulation, 180–81

      computer hacking, 3

      connection, 221–35, 279, 280–81

      Constitution (U.S.), 153, 156, 158, 176

      consummation, 18, 41, 47, 56, 57, 58–59, 273

      See also reward

      consumption, 25, 82, 182–83, 185, 189–90, 191, 221–22, 280–81

      contentment

      defined, 8–9, 18–19, 20, 24, 32

      pathway, 8, 10, 11, 12, 13, 18, 30, 30, 32, 36, 37, 40, 41, 151–52, 222

      reward vs., 2, 7, 8, 9–11, 12, 18, 23–24, 40–41, 221, 282–86

      serotonin and, 8, 10–11, 12, 13, 18, 30, 30, 32, 36, 37, 40, 41

      See also eudemonia; Four Cs of Contentment; hacking of the American mind; happiness; limbic system; neuroscience; serotonin

      continuous positive airway pressure (CPAP), 254–55

      contribution, 10, 222–23, 224, 236–49, 279, 281

      Controlled Substances Enforcement Act of 1970, 114, 120

      conversation, 227–28, 280

      Convit, Antonio, 129

      cooking, 222–23, 279–80, 281

      Coontz, Stephanie, 40

      coping, 222–23, 250–66, 279, 281

      corn, 125–26, 132, 183–84, 239, 284

      corn vs. grass-fed beef, 125–26, 126–27

      corporate consumption complex, 25, 280–81

      corporate “justice,” 177–81

      corporate takeover of our bodies and brains, 4–5, 6, 7, 13, 23, 25, 147, 221–22, 285

      See also hacking of the American mind

      corporation vs. individual, 175–85, 186, 239–41

      correlation vs. causation, 11–12, 129, 130, 145, 193, 227, 240, 257, 268

      cortisol

      addiction and, 70

      dopamine and, 58–59, 68

      dopamine-cortisol-serotonin connection, 137–47, 225, 282–83

      Four Cs of Contentment, 222, 225, 228, 251, 252, 256, 263, 281, 282

      hacking of the American mind, 10, 152, 181, 182, 186, 188, 190, 191, 193–94, 197, 198

      neuroscience, 26

      stress and, 60, 61–62, 67, 142–44, 263

      See also amygdala; stress

      Creative Imagination Scale, 119

      Cricket, Jiminy (character), 60, 63–64

      See also prefrontal cortex

      “cumulative disadvantage over life,” 155

      cyber-b
    ullying, 195

      Dalai Lama, 137

      DATs (dopamine transporters), 54–55, 106, 140, 141, 144

      See also dopamine

      death rates, 61, 153–55, 206, 208–10, 268

      death spiral, 203, 204–14

      Deaton, Angus, 155, 173, 174, 225, 238, 243

      de Bernières, Louis, 39

      Declaration of Independence, 153, 156–57, 158

      dementia, 13, 61, 126, 128, 129, 204, 228, 251, 284

      dendrites, 28

      dependence, 91, 93, 112, 120, 138, 168, 257, 280

      See also addiction

      depression, 2

      addiction and, 25, 70, 75

      dopamine-cortisol-serotonin connection, 138, 140, 142, 144, 145, 146–48, 147

      Four Cs of Contentment, 223, 232, 233, 237, 239, 240, 247, 252, 255, 257, 261, 263, 264, 266, 267, 272, 275, 280–81

      hacking of the American mind, 2, 9, 13, 158, 164, 165, 193, 194, 196–97, 209–10

      neuroscience, 27, 34, 35, 41

      reward and, 51, 55

      serotonin and, 98–100, 99, 101, 103–4, 105, 107, 108, 116, 117–18, 123, 124, 125, 127–28, 129, 130, 131, 134–35, 136

      stress and, 61, 63

      sugar and, 129, 130, 131

      See also happiness

      desire. See motivation

      desire, pleasure, opioids. See dopamine

      device addiction, 194

      diabetes, 1, 5, 13, 27, 61, 67, 90, 92, 126, 127, 128, 129, 155, 159, 187, 204, 205, 206, 207, 208, 209, 210, 212, 216, 217, 256, 267, 269, 276, 284

      Diagnostic and Statistical Manual (DSM), 77, 78, 93

      Dietary Goals for the United States, 88

      digital diet addiction, 235

      dimethyltryptamine (DMT), 113

      disability-adjusted life years (DALYs), 215–16

      docosohexaenoic acid (DHA), 132, 133–34

      Doll paper (smoking and lung cancer), 178

      Donne, John, 151

      DOPA decarboxylase, 52, 52, 102, 102

      dopamine, 45–59

      addiction and, 40, 47, 55–57, 69, 70, 72, 73–74, 75, 76, 79, 80, 81, 82, 83, 86, 87, 130

      bell-shaped curve, 34, 48–51, 49, 53, 55, 59, 64, 67

      cortisol and, 58–59, 68

      dopamine-cortisol-serotonin connection, 137–47, 225, 282–83

      Four Cs of Contentment, 227, 245–46, 248–49, 252, 258, 272–73, 283–84

      hacking of the American mind, 166, 175, 181, 183, 187–88, 189, 191, 192–93, 196, 198

      neuroscience, 36, 37, 38, 39, 41

      reward and, 10–11, 12, 13, 24, 29, 32, 36, 37, 221

     


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