[308] Deldicque, L. et al (2008) 'Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle', J Appl Physiol 1985, Vol 104(2), p 371-8.
[309] Jorquera, G. et al (2013) 'Testosterone signals through mTOR and androgen receptor to induce muscle hypertrophy', Med Sci Sports Exerc, Vol 45(9), p 1712-20.
[310] Altamirano, F. et al (2009) 'Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway', J Endocrinol, Vol 202(2), p 299-307.
[311] Xu, K. et al (2014) 'mTOR signaling in tumorigenesis', BBA, Vol 1846(2), p 638-654.
[312] Lamming, DW. et al (2012) 'Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity', Science, Vol 335(6076), p 1638-1643.
[313] Liberti, M. and Locasale, J. (2016) 'The Warburg Effect: How Does it Benefit Cancer Cells?', Trends Biochem Sci, Vol 41(3), p 211-218.
[314] Yin, Y. et al (2016) 'mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR', Cell Research, Vol 26(1), p 46-65.
[315] Chan, S. (2004) 'Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer', Br J Cancer, Vol 91(8), p 1420-4.
[316] Zoncu, R. et al (2010) 'mTOR: from growth signal integration to cancer, diabetes and ageing', Molecular Cell Biology, Vol 12, p 21-35.
[317] Chano, T. et al (2007) 'RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases', Vol 1168(7), p 97-105.
[318] Selkoe, DJ. (2008) 'Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior', Behavioural Brain Research, Vol 192(1), p 106-113.
[319] Wilson Powers, R. et al (2006) 'Extension of chronological life span in yeast by decreased TOR pathway signaling', Genes Dev, Vol 20(2), p 174-184.
[320] Julie Wu, J. et al (2013) 'Increased mammalian lifespan and a segmental and tissue-specific slowing of aging following genetic reduction of mTOR expression', Cell Rep, Vol 4(5), p 913-920.
[321] Jia, K. et al (2004) 'The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span', Vol 131, p 3897-3906.
[322] Kriete, A. et al (2010) 'Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses', PLOS Computational Biology, Vol 6(6), e1000820.
[323] Melnik, B. (2012) 'Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet', Dermatoendocrinol, Vol 4(1), p 20-32.
[324] Fontana, L. et al (2013) 'Dietary protein restriction inhibits tumor growth in human xenograft models', Oncotarget, Vol 4(12), p 2451-61.
[325] Long, X. et al (2005) 'Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency', J Biol Chem, Vol 280(25), p 23433-6.
[326] Chen, R. et al (2014) 'The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation', JCB, Vol 206(2), p 173.
[327] Martins, L. et al (2012) 'Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin', PLOS One, Vol 7(10), e46923.
[328] McDaniel, S. et al (2011) 'The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway', Epilepsia, Vol 52(3), e7–e11.
[329] Kimball, SR. et al (2004) 'Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase', J Biol Chem, 279(52), p 54103-9.
[330] Watson, K. and Baar, K. (2014) 'mTOR and the health benefits of exercise', Seminars in Cell & Developmental Biology, Vol 36, p 130-139.
[331] Shimizu, H. et al (2010) 'Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures', Peptides, Vol 31(1), p 145-9.
[332] Liu, X. et al (2014) ’Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK', PNAS, Vol 111(4), E435-E444.
[333] Faivre, S. et al (2006), 'Current development of mTOR inhibitors as anticancer agents', Nature Reviews Drug Discovery volume 5, pages 671–688.
[334] Liu, M. et al (2010) 'Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR', J Biol Chem, Vol 285(47), p 36387-94.
[335] Beevers, CS. et al (2006) 'Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells', Int J Cancer, Vol 119(4), p757-64.
[336] Suarez-Arroyo, IJ. et al (2013) 'Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models', PLOS One, Vol 8(2), e57431.
[337] Liu, Z. et al (2012) 'Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy', Mol Carcinog, Vol 51(3), p 257-67.
[338] Law, PC. et al (2012) 'Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells', The official journal of the International Society for Complementary Medicine Research (ISCMR)201212:160.
[339] Lee, YK. et al (2010) 'Anthocyanins are novel AMPKα1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation', Oncol Rep, Vol 24(6), p 1471-7.
[340] Banerjee, N. et al (2013) 'Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR', Carcinogenesis, Volume 34, Issue 12, 1 December 2013, Pages 2814–2822.
[341] Hong-Brown, LQ. et al (2013) 'Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes', Alcohol Clin Exp Res, Vol 37(11), p 1849-61.
[342] Zhou, R. et al (2011) 'Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells', J Orthop Res, Vol 29(6), p 846-52.
[343] Zhang, Z. et al (2014) 'Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling', J Cancer, Vol 5(5), p 382-9.
[344] Brook, MS. et al (2015) 'Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise', Acta Physiologica, Vol 216(1), p 15-41.
[345] Brioche, T. et al (2016) 'Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention', Molecular Aspects of Medicine, Vol 50, p 56-87.
[346]Wang, Y. et al (2010) 'Coordinate Control of Host Centrosome Position, Organelle Distribution, and Migratory Response by Toxoplasma gondii via Host mTORC2', JBC, Vol 285, p 15611-15618.
[347] Myamoto, S. et al (2008) 'Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II', Cell Death Differ, Vol 15(3), p 521-9.
[348] Laplante, M. and Sabatini, D. (2012) 'mTOR Signaling in Growth Control and Disease', Cell, Vol 149(2), p 274-293.
[349] Betz, C. et al (2013) 'mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology', PNAS, Vol 110(31), p 12526-12534.
[350] Kohn, AD. et al (1996) 'Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation', J Biol Chem, Vol 271(49), p 31372-8.
[351] Hoeffer, CA. and Klann, E. (2010) 'mTOR signaling: At the crossroads of plasticity, memory and disease', Trends in Neuroscience, Vol 33(2), p 67-75.
[352] Kougias, DG. et al (2016) 'Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats', Neurobiology of Aging, Vol 40, p 78-85.
[353] Watson, K. and Baar, K. (2014) 'mTOR and the health benefits of exercise', Seminars in Cell & Developmental Biology, Vol 36, p 130-139.
[354] Ricoult, SJ. and Manning, BD. (2013) 'The multifaceted role of mTORC1 in the control of lipid metabolism', EMBO Rep, Vol 14(3), p 242-51.
[355] Sengupta, S. et al (2010) 'mTORC1 controls fasting-induced ketogenesis and its modulation by ageing', Nature, Vol 468(7327), p 1100-4.
[356] Higashi, Y. et al (2013) 'Insulin-Like Growth Factor-1 Regulates Glutathione Peroxidase Expression and Activity in Vascular Endothelial Cells: Implications for Atheroprotective Actions of Insulin-Like Growth Factor-1', Biochim Biophys Acta, Vol 1832(3), p 391-399.
[357] Higashi, Y. et al (2014) 'The Interaction Between IGF-1, Atherosclerosis and Vascular Aging', Front Horm Res, Vol 43, p 107-124.
[358] Ni, F. et al (2013) 'IGF-1 promotes the development and cytotoxic activity of human NK cells', Nat Commun, Vol 4, p 1479.
[359] Puche, JE. et al (2012) 'Human conditions of insulin-like growth factor-I (IGF-I) deficiency', J Transl Med, Vol 10, p 224.
[360] Yang, Y. and Yee, D. (2012) 'Targeting Insulin and Insulin-Like Growth Factor Signaling in Breast Cancer', Journal of Mammary Gland Biology and Neoplasia, Vol 17(3-4), p 251-261.
[361] Kenyon, C. et al (1993) 'A C. elegans mutant that lives twice as long as wild type', Nature volume 366, pages 461–464.
[362] Sattler, F. (2013) 'Growth hormone in the aging male', Clinical Endocrinology & Metabolism, Vol 27(4), p 541-555.
[363] Levine, M. et al (2014) 'Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population', Cell Metabolism, Vol 19(3), p 407-417.
[364] Puche, JE. and Castilla-Cortázar I. (2012) 'Human conditions of insulin-like growth factor-I (IGF-I) deficiency', J Transl Med, Vol 10, p 224.
[365] Burgers, AMG. et al (2011) 'Meta-Analysis and Dose-Response Metaregression: Circulating Insulin-Like Growth Factor I (IGF-I) and Mortality', JCEM, Vol 96(9), p 2912-2920.
[366] Barbier, M. et al (2009) 'Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects', Mech Ageing Dev, Vol 130(11-12), p 771-6.
[367]Lewis, ME. et al (1993) 'Insulin-like Growth Factor-I: Potential for Treatment of Motor Neuronal Disorders', Experimental Neurology, Vol 124(1), p 73-88.
[368] Lichtenwalner RJ, et al (2001) 'Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis', Neuroscience, Vol 107(4), p 603-13.
[369]Aleman, A. et al (1999) 'Insulin-like growth factor-I and cognitive function in healthy older men', J Clin Endocrinol Metab, Vol 84(2), p 471-5.
[370] Carro, E. et al (2002) 'Serum insulin-like growth factor I regulates brain amyloid-beta levels', Nat Med, Vol 8(12), p 1390-7.
[371] Straub, RH. (2014) 'Interaction of the endocrine system with inflammation: a function of energy and volume regulation', Arthritis Research & Therapy, Vol 16(1), p 203.
[372] Kim, T. et al (2015) 'Intense Walking Exercise Affects Serum IGF-1 and IGFBP3', J Lifestyle Med, Vol 5(1), p 21-25.
[373] El-Bahr SM (2013) 'Curcumin regulates gene expression of insulin like growth factor, B-cell CLL/lymphoma 2 and antioxidant enzymes in streptozotocin induced diabetic rats', BMC Complement Altern Med, Vol 13, p 368.
[374] Wang, LM. et al (2012) 'Luteolin inhibits proliferation induced by IGF-1 pathway dependent ERα in human breast cancer MCF-7 cells', Asian Pac J Cancer Prev, Vol 13(4), p 1431-7.
[375] Li, X. et al (2013) 'Epigallocatechin-3-gallate inhibits IGF-I-stimulated lung cancer angiogenesis through downregulation of HIF-1α and VEGF expression', J Nutrigenet Nutrigenomics, Vol 6(3), p 169-78.
[376] Lammintausta R. et al (1976) 'Change in hormones reflecting sympathetic activity in the Finnish sauna', Ann Clin Res, Vol 8(4), p 266-71.
[377] Burd NA et al. (2010) Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men, PLOS One, Vol 5(8), e12033.
[378] Häkkinen, K. et al (2003) 'Neuromuscular adaptations during concurrent strength and endurance training versus strength training', Eur J Appl Physiol, Vol 89(1), p 42-52.
[379] Schoenfeld BJ et al (2016) 'Effects of Resistance Training Frequency on Measures of Muscle Hypertrophy: A Systematic Review and Meta-Analysis', Sports Med, Vol 46(11), p 1689-1697.
[380] Schoenfeld BJ et al (2015) 'Influence of Resistance Training Frequency on Muscular Adaptations in Well-Trained Men', J Strength Cond Res, Vol 29(7), p 1821-9.
[381]Rafael, Z. et al (2018) 'High Resistance-Training Frequency Enhances Muscle Thickness in Resistance-Trained Men', The Journal of Strength & Conditioning.
[382] Cadore, EL. et al (2008) 'Hormonal responses to resistance exercise in long-term trained and untrained middle-aged men', J Strength Cond Res, Vol 22(5), p 1617-24.
[383] Ochi, E. et al (2018) 'Higher Training Frequency Is Important for Gaining Muscular Strength Under Volume-Matched Training', Frontiers in Physiology 02 July 2018.
[385] Heymsfeld, S. et al (1982) Biochemical composition of muscle in normal and semistarved human subjects: Relevance to anthropometric measurements, American Journal of Clinical Nutrition (USA)
[386] Demling, RH. and DeSanti, L. (2000) 'Effect of a hypocaloric diet, increased protein intake and resistance training on lean mass gains and fat mass loss in overweight police officers', Ann Nutr Metab, Vol 44(1), p 21-9.
[387] Nindl, BC. et al (2000), 'Regional body composition changes in women after 6 months of periodized physical training', J Appl Physiol (1985), Vol 88(6), p 2251-9.
[388] Paoli, A. et al (2012) 'Ketogenic diet does not affect strength performance in elite artistic gymnasts', J Int Soc Sports Nutr, Vol 9, p 34.
[389] Garthe, I. et al (2011) 'Effect of two different weight-loss rates on body composition and strength and power-related performance in elite athletes', Int J Sport Nutr Exerc Metab, Vol 21(2), p 97-104.
[390] Pascoe DD, et al (1993), 'Glycogen resynthesis in skeletal muscle following resistive exercise', Med Sci Sports Exerc, Vol 25(3), p 349-54.
[391] Fournier, PA. et al (2004) 'Post-Exercise Muscle Glycogen Repletion in the Extreme: Effect of Food Absence and Active Recovery', J Sports Sci Med, Vol 3(3), p 139-146.
[392] Peters Futre, EM. et al (1987) 'Muscle glycogen repletion during active postexercise recovery', American Journal of Physiology, Vol 253(3), p E305-E311.
[393] Ho, KY. et al (1988) 'Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man', J Clin Invest, Vol 81(4), p 968-975.
[394]Röjdmark S, (1989) 'Pituitary-testicular axis in obese men during short-term fasting', Acta Endocrinol (Copenh), Vol 121(5), p 727-32.
[395] Patterson, RE. et al (2015) 'INTERMITTENT FASTING AND HUMAN METABOLIC HEALTH', J Acad Nutr Diet, Vol 115(8), p 1203-1212.
[396] Masiero, E. et al (2009) 'Autophagy is required to maintain muscle mass', Cell Metabolism, Vol 10(6), p 507-15.
[397] Young, CM. et al (1971) 'Effect of body composition and other parameters in obese young men of carbohydrate level of reduction diet', Am J Clin Nutr, Vol 24(3), p 290-6.
[398] Kadowaki, M. et al (1996) 'Acute effect of epinephrine on muscle proteolysis in perfused rat hindquarters', Am J Physiol, Vol 270(6 Pt 1), p E961-7.
[399] Nair KS et al (1988) 'Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans', J Clin Invest, Vol 82(1), p 198-205.
[400] Layman DK et al (2005) 'Dietary protein and exercise have additive effects on body composition during weight loss in adult women', J Nutr, Vol 135(8), p 1903-10.
[401] Layman DK and Walker DA (2006) 'Potential importance of leucine in treatment of obesity and the metabolic syndrome', J Nutr, Vol 136(1 Suppl):319S-23S.
[402] Slater GJ and Jenkins D (2000) 'Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength', Sports Med, Vol 30(2), p 105-16.
; [403] Harber MP et al (2005) 'Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis', J Clin Endocrinol Metab, Vol 90(9), p 5175-81.
[404] Thissen, JP et al (1994) 'Nutritional regulation of the insulin-like growth factors', Endocr Rev, Vol 15(1), p 80-101.
[405] Guo, W. et al (2011) 'Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling', J Neurosci Res, Vol 89(11), p 1723-36.
[406] Ghosh HS, McBurney M, Robbins PD. (2010) ‘SIRT1 negatively regulates the mammalian target of rapamycin’, PLoS One, 2010 Feb 15, Vol 5(2), e9199.