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    DNA USA

    Page 36
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      Donald Gallach MacDonald, 3rd of Sleat

      d. 1506

      H

      Ranald Mor MacDonald, 7th of Keppoch

      d. 1547

      I

      Alan MacDonald, 4th of Clanranald

      1437–1481

      J

      Donald Gruamach MacDonald, 4th of Sleat

      d. 1534

      K

      Ian Moidartach MacDonald, 8th of Clanranald

      1502–1584

      L

      Sir Donald Breac Macdonald, 10th of Sleat

      1605–1678

      M

      Ranald Alexander MacDonald, 24th of Clanranald

      Living

      Clanranald

      N

      P. M. Macdonald

      Living

      Glenaladale

      O

      J. J. Macdonald

      Living

      Bornish

      P

      Ranald MacDonell, 23rd of Glengarry

      Living

      Glengarry

      Q

      Allan Douglas MacDonald of Vallay

      Living

      Vallay

      R

      Sir Iain Godfrey MacDonald, 25th of Sleat

      Living

      Sleat

      S

      David Foster Macdonald, 17th of

      Castle Camus

      Living

      Castle Camus

      T

      D. B. Macdonald

      Living

      Sleat

      U

      W. F. Macdonald

      Living

      Achnancoichean

      V

      L. McDonald

      Living

      Bohuntin

      Details of Y chromosome mutations in Clan Donald genealogy (See Fig.2)

      LINK

      MARKER

      MUTATION

      C–E

      458

      16–15

      E–G

      557

      15–16

      F–P

      449

      31–32

      F–P

      456

      17–16

      F–P

      CDYa

      34–35

      G–T

      GATAH4

      12–11

      H–U

      448

      20–21

      H–U

      449

      30–31

      H–U

      GATAH4

      12–11

      H–V

      570

      18–19

      H–V

      390

      25–24

      I–O

      CDYb

      38–37

      J–L

      448

      20–19

      J–S

      449

      31–32

      J–S

      460

      11–10

      J–S

      557

      15–17

      K–M

      389a

      14–13

      K–M

      390

      25–24

      K–M

      449

      31–32

      K–M

      576

      17–18

      K–M

      CDYb

      38–37

      K–N

      GATAH4

      12–10

      K–N

      CDYa

      34–33

      K–N

      449

      31–30

      K–N

      458

      15–16

      L–R

      607

      16–15

      Code letters in column 1 identify deceased (shaded) and living individuals on Fig. 2 (p. 108). Markers 1–38 are identified in row 2.

      Numbers in table body are allele repeat lengths of Y chromosomes that differ from values deduced for Somerled (row A)

      The location of 146 important genes, showing their order from right to left along each chromosome (Column 1), the body system involved (Column 2), the encoded protein (Column 3), and the international gene symbol (Column 4).

      REF

      SYSTEM

      PROTEIN

      SYMBOL

      1.1

      Digestion

      Chymotrysin C

      CTRC

      1.2

      Bones, skin, teeth, and joints

      Bone morphogenetic protein 8a/b

      BMP8A/B

      1.3

      Metabolism

      Leptin receptor

      LEPR

      1.4

      Digestion

      Amylase

      AMY1 and 2

      1.5

      Digestion

      Cathepsin K and S

      CTSK/S

      1.6

      Muscle

      Tropomyosin 3

      TPM3

      1.7

      Brain and nerves

      Laminin gamma 2

      LAMC2

      1.8

      Liver and kidney

      Renin

      REN

      1.9

      Muscle

      Actin alpha 1, skeletal muscle

      ACTA1

      1.10

      Eyes

      Opsin 3

      OPN3

      2.1

      Immunity

      Immunoglobulin kappa constant

      IGKC

      2.2

      Bones, skin, teeth, and joints

      Bone morphogenetic protein 10

      BMP10

      2.3

      Digestion

      Lactase

      LCT

      2.4

      Brain and nerves

      Sodium channel 9

      SCN9A

      2.5

      Heart and lung

      Collagen type 3

      COL1A3

      2.6

      Eyes

      Crystallin gamma A

      CRYGA

      2.7

      Pigmentation

      Fibronectin

      FN1

      2.8

      Eyes

      Crystallin beta A2

      CRYBA2

      2.9

      Liver and kidney

      Collagen type 4,

      alpha 3/4

      COL4A3/4

      2.10

      Metabolism

      Glucagon

      GCG

      3.1

      Eyes

      Retinoic acid receptor beta

      RARB

      3.2

      Metabolism

      Parathyroid hormone 1 receptor

      PTH1R

      3.3

      Digestion

      Lactotransferrin

      LTF

      3.4

      Metabolism

      Phosphodiesterase

      PDE12

      3.5

      Muscle

      Myosin HC 15

      MYH15

      3.6

      Eyes

      Rhodopsin

      RHO

      4.1

      Brain and nerves

      Huntingtin

      HTT

      4.2

      Bones, skin, teeth, and joints

      Fibroblast growth factor 3

      FGFR3

      4.3

      Bones, skin, teeth, and joints

      Enamalin

      ENAM

      4.4

      Bones, skin, teeth, and joints

      Ameloblastin

      AMBN

      4.5

      Immunity

      Immunoglobulin J

      IGJ

      4.6

      Liver and kidney

      Alcohol dehydrogenase

      ADH1A

      4.7

      Pigmentation

      Hair color 2 (red)

      HCL2

      5.1

      Blood

      Thrombospondin 4

      THBS4

      5.2

      Muscle

      Myosin X

      MYOX

      5.3

      Pigmentation

      Solute carrier, family 45, member A2

      SLC45A2

      5.4

      Bones, skin, teeth, and joints

      Growth hormone receptor


      GHR

      5.5

      Bones, skin, teeth, and joints

      Fibroblast growth factor 10

      FGF10

      5.6

      Bones, skin, teeth, and joints

      Fibrillin 2

      FBN2

      5.7

      Bones, skin, teeth, and joints

      Lysyl oxidase

      LOX

      5.8

      Bones, skin, teeth, and joints

      Fibroblast growth factor 1

      FGF1

      5.9

      Metabolism

      Insulin dependent diabetes 10

      IDDM10

      6.1

      Immunity

      HLA region

      HGC

      6.2

      Eyes

      Opsin 5

      OPN5

      6.3

      Muscle

      Myosin VI

      MYO6

      6.4

      Brain and nerves

      Laminin alpha 2/4

      LAMA2/4

      6.5

      Brain and nerves

      Opioid receptor mu 1

      OPRM1

      6.6

      Blood

      Plasminogen

      PLG

      6.7

      Blood

      Thrombospondin 2

      THBS2

      7.1

      Muscle

      Actin beta

      ACTB

      7.2

      Muscle

      Myosin light chain 7

      MYL7

      7.3

      Bones, skin, teeth, and joints

      Elastin

      ELN

      7.4

      Blood

      Erythropoietin

      EPO

      7.5

      Bones, skin, teeth, and joints

      Collagen type 1, alpha 2

      COL1A2

      7.6

      Brain and nerves

      Acetylcholinesterase

      ACHE

      7.7

      Eyes

      Opsin 1 cone short wave

      OPN1SW

      7.8

      Brain and nerves

      Olfactory receptor 2A.25

      OR2A25

      8.1

      Heart and lung

      Surfactant protein C

      SFTPC

      8.2

      Bones, skin, teeth, and joints

      Fibroblast growth factor receptor 1

      FGFR1

      8.3

      Blood

      Plasminogen activator (tissue)

      HBB

      8.4

      Brain and nerves

      Opioid receptor kappa 1

      OPRK1

      8.5

      Blood

      Angiopoietin 1

      ANGPT1

      8.6

      Brain and nerves

      Otoconin

      OC90

      9.1

      Immunity

      Inteferon alpha

      IFNA

      9.2

      Muscle

      Tropomyosin 2

      TPM2

      9.3

      Digestion

      Beta glucosidase (bile acid)

      GBA2

      9.4

      Bones, skin, teeth, and joints

      Osteoclast stimulating factor 1

      OSTF1

      9.5

      Bones, skin, teeth, and joints

      Osteoglycin

      OGN

      9.6

      Blood

      Hemogen

      HEMGN

      9.7

      Blood

      ABO blood group

      ABO

      10.1

      Eyes

      Optineurin

      OPTN

      10.2

      Muscle

      Myosin IIIA

      MYO3A

      10.3

      Eyes

      Opsin 4

      OPN4

      10.4

      Muscle

      Actin alpha 2, smooth muscle

      ACTA2

      10.5

      Digestion

      Trypsin

      TYSND1

      10.6

      Heart and lung

      Adrenergic alpha 2A/beta receptor

      ADRA2A/B1

      10.7

      Metabolism

      Cytochrome P450, family 2C, polypeptide

      CYP2C9

      10.8

      Heart and lung

      Pancreatic lipase

      PNLIP

      11.1

      Blood

      Beta globin

      HBB

      11.2

      Metabolism

      Insulin

      INS

      11.3

      Brain and nerves

      Otogelin

      OTOG

      11.4

      Digestion

      Pepsin

      PGA3

      11.5

      Digestion

      Cathepsin C

      CTSC

      11.6

      Pigmentation

      Tyrosinase

      TYR

      11.7

      Eyes

      Crystallin alpha B

      CRYAB

      11.8

      Immunity

      Thymocyte cell surface antigen

      THY1

      12.1

      Immunity

      Alpha 2 macroglobulin

      A2M

      12.2

      Digestion

      Islet amyloid polypeptide

      IAPP

      12.3

      Pigmentation

      Keratin 1-5

      KRT1-5

      12.4

      Bones, skin, teeth, and joints

      Collagen type 2

      COL2A1

      12.5

      Digestion

      Peptidase B

      PEPB

      12.6

      Pigmentation

      KIT ligand

      KITLG

      12.7

      Immunity

      Thympoietin

      TMPO

      12.8

      Digestion

      Phopholipase A2

      PLA2G1B

      13.1

      Brain and nerves

      Olfactomedin 4

      OLFM4

      13.2

      Brain and nerves

      Olfactory receptor E

      OR7E

      13.3

      Muscle

      Myosin XVI

      MYO16

      13.4

      Liver and kidney

      Collagen type 4, alpha 1 and 2

      COL4A1/2

      14.1

      Heart and lung

      Myosin heavy chain 6 and 7, cardiac

      MYH6/7

      14.2

      Metabolism

      Estrogen receptor 2

      ESR2

      14.3

      Bones, skin, teeth, and joints

      Bone morphogenetic protein 4

      BMP4

      14.4

      Blood

      Spectrin beta

      SPTB

      14.5

      Digestion

      Chymotrypsin

      CTRB1

      14.6

      Brain and nerves

      Creatine kinase (brain)

      CKB

      14.7

      Immunity

      Immunoglobulin H alpha 1

      IGHA1 et al.

      15.1

      Muscle

      Actin alpha 1, cardiac muscle

      ACTC1

      15.2

      Pigmentation

      Oculocutaneous albinism II

      OCA2

      15.3

      Brain and nerves

      Cholinergic receptor nicotinic alpha 7

      CHRNA7

      15.4

      Pigmentation

      Solute carrier, family 24 member 5

      SLC24A5

      15.5

      Blood

      Thrombospondin 1

      THBS1

      15.6

      Muscle

      Myosin 1E

      MYO1E

      15.7

      Pigmentation

      Hair color 3 (brown)

      HCL3

      15.8

      Bones, skin, teeth, an
    d joints

      Chondroitin sulfate proteoglycan 4

      CSPG4

      15.9

      Bones, skin, teeth, and joints

      Aggrecan

      ACAN

      16.1

      Blood

      Alpha globin

      HBA1 and 2

      16.2

      Digestion

      Myosin HC 11, smooth muscle

      MYH11

      16.3

      Blood

      Alpha hemoglobin stabilizing protein

      AHSP

      16.4

      Muscle

      Myosin light chain kinase 3

      MYLK3

      16.5

      Blood

      Haptoglobin

      HP

      16.6

      Digestion

      Chymotrypsinogen B1/2

      CTRB1/2

      16.7

      Pigmentation

      Melanocortin 2 receptor

      MC2R

      17.1

      Muscle

      Myosin, heavy chain 1, skeletal adult

      MYH1-4

      17.2

      Eyes

      Crystallin beta A1

      CRYBA1

      17.3

      Bones, skin, teeth, and joints

      Collagen type 1, alpha 1

      COL1A1

      17.4

      Digestion

      Gastrin

      GAST

      17.5

      Heart and lung

      Angiotensin 1 converting enzyme

      ACE

      17.6

      Metabolism

      Glucagon receptor

      GCGR

      17.7

     


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